Vol. 04 · Issue 26 Trade Briefing Buyer-Restricted 28 · 04 · 2026
A Briefing for Category Buyers

Eight active ingredients. One liquid bottle.
The most fully-disclosed joint formula your shelf can carry.

Super Collagen 22oz is a single-bottle, four-pathway joint system — structural rebuild, inflammation modulation, cartilage protection, and synovial lubrication — engineered for the buyer who is tired of stocking eight half-dosed jars to do what one bottle does.

Open Wholesale Account See the Margin Math Sell-sheet PDF · COA on request
Account · Snapshot Updated daily
MSRP / Bottle
$44.99
$22.50 to retailer · 50% margin
12-Mo Re-Order
71%
vs. category avg 38%
Avg Units / Wk / Door
3.4
$76.50 weekly contribution
Opening Order MOQ
4 cs
48 bottles · ~6-wk supply
Net-30 on approval FOB Atlanta · 7-day lead
Nutra Botanics · Joint Plus
Super
CollagenLiquid Hydrolyzed Peptides
6,000 mg Per Serving · 32 Servings
22 fl oz · Tropical · Stevia
Active Ingredients 8 disclosed
Pathways Engaged 4 of 4
Sweetener Stevia · 0g sugar
Super Collagen Joint Plus · 22 fl oz SKU · NB-SC22-LIQ-TRO  ·  Case 12
Section01
The Numbers, First

Buyers don't decide on a story. They decide on the math.

A 50-point margin on a $45 bottle is good. A 50-point margin on a $45 bottle that re-orders at 71% over twelve months is rare. Below: the unit economics, then the velocity.

Units per caseOne bottle = one consumer · 4-week supply
12
Wholesale / unitNet-30 on approval · FOB Atlanta
$22.50
MAP retail / unitMAP-enforced across all channels
$44.99
Cases / order6 cases
Order subtotal Per opening or re-order
$1,620.00
Retail value at sell-through
$3,239.28
Gross profit (you keep)
$1,619.28
Effective margin
50.0%

Co-op marketing rebate of 4% kicks in at 6+ cases · Free freight at 12+ cases · Re-order accounts qualify for Net-45 after the third on-time payment.

Where 22oz lands against the rest of your joint set.

Powder cans
$24
Capsules
$31
Gummies
$42
Liquid (cat. avg)
$54
Super Collagen 22oz
$76

Internal trailing-12-mo blended data across 47 independent natural-channel doors and 9 regional pharmacy accounts. Per-facing-per-week dollar contribution. Does not constitute a forward earnings projection.

Section02
The Multi-Pathway System

Joint discomfort is not one problem. Most products treat it like it is.

Inflammation, cartilage breakdown, lubrication loss, and matrix depletion run on four different biological pathways. Super Collagen 22oz is the only liquid joint formula in the natural channel that addresses all four — with a transparent, peer-reviewed dose stack on every label.

Four-pathway joint inflammation map showing how each Super Collagen 22oz active modulates a distinct biological pathway converging on the joint. PATHWAY 01 / STRUCTURAL REBUILD PATHWAY 03 / CARTILAGE PROTECTION PATHWAY 02 / INFLAMMATION SUPPRESSION PATHWAY 04 / SYNOVIAL LUBRICATION HYDROLYZED COLLAGEN 6,000 mg · Type I+III GLUCOSAMINE 400 mg VITAMIN C 75 mg → Pro-Hyp dipeptide signal → GAG / proteoglycan precursor → Fibroblast collagen-synthesis cofactor TURMERIC EXTRACT 200 mg · 95% curcuminoids ↓ NF-κB activation ↓ COX-2 · ↓ TNF-α · ↓ IL-6 Cytokine cascade ↓ Master inflammation switch Downstream signaling silenced CHONDROITIN SULFATE 300 mg ↓ MMP-1 · MMP-3 · MMP-13 ↓ Catabolic enzyme activity → Matrix-degrading enzyme block → Cartilage matrix preserved → Curcumin · vitamin C synergy HYALURONIC ACID 100 mg OPTI-MSM 300 mg BIOTIN 15 mcg Synovial fluid viscosity ↑ Sulfur donor · waste clearance Connective-tissue cofactor Joint Function CONVERGED OUTCOME DIAGRAM IS ILLUSTRATIVE OF PEER-REVIEWED PATHWAY LITERATURE · NOT A PRODUCT CLAIM
PATHWAY 01 Structural Rebuild

Feed the matrix the building blocks it's running out of.

Hydrolyzed peptides deliver glycine, proline, hydroxyproline — and Pro-Hyp dipeptides that signal chondrocytes to up-regulate cartilage matrix synthesis.

Actives: Collagen 6,000 mg · Glucosamine 400 mg · Vitamin C 75 mg
PATHWAY 02 Inflammation Suppression

Quiet the cytokine cascade at the master switch.

Curcumin's NF-κB inhibition is one of the most-studied anti-inflammatory pathways in the literature — downstream TNF-α, IL-6, and COX-2 signaling all attenuate.

Actives: Turmeric 200 mg (95% curcuminoids)
PATHWAY 03 Cartilage Protection

Block the enzymes that chew through cartilage.

Matrix metalloproteinases (MMP-1, -3, -13) drive cartilage breakdown. Chondroitin and curcuminoid co-action down-regulate this catabolic enzyme family.

Actives: Chondroitin 300 mg · Turmeric synergy · Vitamin C
PATHWAY 04 Synovial Lubrication

Restore the fluid the joint glides on.

Hyaluronic acid is the structural lubricant of synovial fluid. MSM contributes the sulfur every connective-tissue protein needs, and clears metabolic waste from the joint capsule.

Actives: HA 100 mg · MSM 300 mg · Biotin 15 mcg
Section03
Every Active. Every Dose. Every Pathway.

The label your buyer-rep actually wants to read.

Eight active ingredients. Zero proprietary blends. Every milligram disclosed in the rear panel — the same data the formulator works from is the same data the educator stocks the shelf with.

Ingredient
Per Serving
Pathway
Mechanism (peer-reviewed)
Reference Class
Hydrolyzed CollagenType I + Type III · Bovine
6,000mg
P1 · Structural
Pro-Hyp dipeptide signaling stimulates chondrocyte synthesis of cartilage extracellular matrix; provides amino-acid substrate for fibroblast collagen production.
PMC10058045 · J. Joint Diseases 2025 · meta-analysis JOSR 2023
Glucosamine SulfateMarine-derived crystalline
400mg
P1 · Structural P4 · Lubrication
Direct precursor for glycosaminoglycan (GAG) and proteoglycan biosynthesis; stimulates synoviocytes to secrete hyaluronic acid into the synovial fluid.
Reviewed in published joint-supplement composition literature, 2023–2026.
Chondroitin SulfateUSP-grade
300mg
P3 · Protection
Down-regulates catabolic matrix metalloproteinase activity in cartilage tissue; complementary to glucosamine in matrix preservation.
PMC peer-reviewed reviews of chondroprotective agents.
OptiMSM®Distilled methylsulfonylmethane
300mg
P4 · Lubrication
Bioavailable sulfur donor for connective-tissue proteins; supports clearance of metabolic by-products from the joint capsule, enhancing glucosamine cellular uptake.
OptiMSM® branded ingredient · published bioavailability studies.
Turmeric Extract95% curcuminoids · standardized
200mg
P2 · Inflammation P3 · Protection
Inhibits NF-κB activation upstream of TNF-α, IL-6, and COX-2; suppresses MMP-1, MMP-3, MMP-13 expression in chondrocytes.
Extensively reviewed curcumin pathway literature, 2018–2026.
Hyaluronic AcidSodium hyaluronate
100mg
P4 · Lubrication
Structural lubricant of synovial fluid; supports joint-space hydration and viscosity, reducing physical friction during articulation.
Peer-reviewed connective-tissue hydration literature.
Vitamin CAscorbic acid · 83% DV
75mg
P1 · Structural P3 · Protection
Required cofactor for fibroblast collagen synthesis (proline / lysine hydroxylation); modulates NF-κB activity and reduces MMP-3 in chondrocytes.
Established biochemical literature · vitamin C–collagen pathway.
BiotinVitamin B7 · 50% DV
15mcg
P4 · Lubrication
Co-factor in keratin and connective-tissue metabolism; complements collagen-led hair, skin, and nail support common to liquid joint shoppers.
Published B7 metabolism literature.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Section04
Format Math

Three formats walk past your shelf. One stops.

Liquid is the fastest-growing format in the joint category for a reason: it skips capsule fatigue, dosing math, and powder mess. Here is how the three primary formats actually compete on shelf — and how Super Collagen 22oz lifts the format.

Format · Capsule

Capsules
& tablets

Daily pill burden4–8 caps
Dose vs. label~62% intake
Avg compliance @ 30d41%
Re-order @ 90d29%
Capsule joint stacks lose the consumer to pill fatigue before the formula has a chance to work.
Format · Powder

Powder
tubs

Daily prepScoop + mix
Dose vs. label~78% intake
Avg compliance @ 30d54%
Re-order @ 90d38%
Strong compliance among habitual mixers; falls off the moment the morning routine is disrupted.
Format · Liquid

Super Collagen
22 oz Liquid

Daily prep1 fl oz · cap-pour
Dose vs. label98% intake
Avg compliance @ 30d81%
Re-order @ 90d71%
Pre-dissolved peptides, full dose every pour, four-week supply per bottle. Compliance is the silent variable that drives every re-order metric on this page.

Compliance and re-order figures are blended internal metrics across 47 independent natural-channel doors / 9 regional pharmacy accounts (trailing 12 months). Dose-vs-label figures derived from category-published intake studies on capsule, powder, and liquid supplement formats.

Section05
Category Gap Analysis

The empty quadrant on every joint set we've ever audited.

← Single-action Multi-pathway →
Mass-Market →
↑ Premium-Liquid
Drugstore caps
Glucosamine + chondroitin caps
Powder collagen tubs
DTC liquid (1 active)
Premium curcumin shots
Super Collagen 22oz

Buyers ask: "who else is doing this?"
The honest answer is: nobody on your shelf.

The natural-channel joint set is dense at the bottom-left — single-active capsules and drugstore stacks. It thins out as you move up-and-right toward premium liquid + multi-pathway. Above the price-point of $35, the multi-pathway liquid quadrant is functionally empty.

  • Gap 1No dominant brand owns "premium liquid joint" in the natural channel — it's a category opening, not a category fight.
  • Gap 2Most multi-pathway joint formulas hide ingredients in a proprietary blend. Disclosed-mg labels are a competitive moat.
  • Gap 3Liquid formats command 1.7× the unit-price ceiling of capsules without losing velocity — the format is under-priced category-wide.
  • Gap 4The 22 oz SKU positions as a 30-day routine in one purchase — a built-in re-order rhythm your POS data will love.
Section06
Trust Stack

Risk-removal, line by line.

Buyers don't reject products that fail. Buyers reject products that introduce uncertainty. Below: the six categories of risk a category manager evaluates before authorizing a new line — and exactly how this brand answers each one.

01 / Compliance

Energy-field-safe label language. Full FDA disclaimer.

Zero diagnostic claims, zero "clinically proven" language, no implied medical positioning. Studied / researched / peer-reviewed framing only. Disclaimer present on every channel touch.

Category — Regulatory
02 / Transparency

Eight actives, every milligram disclosed.

No proprietary blends. No hidden cofactors. No "complex." The label and the formulator's spec sheet match. Educators sell what they understand — this label is built to be understood in thirty seconds.

Category — Formulation
03 / Manufacturing

USA-manufactured. cGMP-compliant facility.

Single-source US production. cGMP-aligned manufacturing partner. Certificate of Analysis available on every batch by SKU — provided to retailers on request prior to opening order.

Category — Supply
04 / Reliability

7-day re-order lead. Free freight at 12 cases.

Inventory held at FOB Atlanta. No "ships in 4–6 weeks." Auto-reorder available on standing accounts; we hold safety stock against your trailing-30 velocity, not against guesswork.

Category — Logistics
05 / Consumer Trust

90-day money-back guarantee.

Full refund — including shipping — within 90 days, no return required. Backed by us, not the retailer. The shelf is risk-free for the consumer, which means the SKU is risk-free for you.

Category — Returns
06 / Channel Discipline

MAP enforced. Direct-to-Amazon priced level.

Map-enforced across all channels. We do not undercut our retail partners on our own DTC site. The brand defends your shelf price — that's a written commitment, not a courtesy.

Category — Pricing
Section07
Sell-Through Support

The shelf is the start. Then we go to work.

Retailer support that actually gets used: physical POS, planogram-ready, staff training, and demo-day kits. Provided free with opening order — none of it sits in a back-room box.

Planogram & shelf-talker kit

Pre-designed planogram for 1-, 3-, and 6-facing layouts. Magnetic shelf-talkers, channel-strip pricers, and the four-pathway POS card included with opening order.

Free · ships with opening order

Staff training video (12 min)

A focused training that walks your floor educators through the four pathways, the eight actives, and the three buyer objections they'll hear most often. Closed-caption · downloadable.

On-demand · LMS-compatible

Demo-day kit (sampling)

1 oz tropical sampler cups, branded pourer station, and a printed take-home insert with the pathway diagram. Free with first order of 6+ cases. Books a sampling Saturday in 2 weeks.

On request · 6+ cases

Consumer-facing micro-site QR

QR code on every shelf-talker drives to a customer-facing pathway page (no diagnostic claims, full disclaimer) — turns the shelf into an educator even when staff is busy.

Always live · trackable

Direct broker access

Every approved account is paired with a single named brand contact. No queue, no ticket. One number, one inbox, one human with full visibility on your account.

Mon–Fri · 8a–6p ET

Co-op marketing (4%)

4% off invoice rebated as marketing credit on orders of 6+ cases. Use it on circulars, in-store demos, regional digital — your call, no pre-approval friction.

Auto-applied · 6+ cases
Section08
Open the Account

One form. One business day. One named contact for the life of the account.

Tell us about your store, what you're carrying today, and where Super Collagen 22oz might land on your set. We'll respond within one business day with a wholesale price sheet, current COA on the live batch, and a planogram suggestion for your specific footprint.

Lead time1 business day to wholesale price sheet + COA
MOQ4 cases (48 bottles) opening order
TermsNet-30 on approval · prepaid otherwise
FreightFOB Atlanta · free at 12+ cases
Co-op4% marketing rebate on 6+ cases

Trade-only inquiries · we don't share data · response within 1 business day